Adobe Animate.
compiledClipInstance.colorMode
Property; a string that specifies the color mode, as identified in the Symbol Properties dialog. Valid values are "none", "brightness", "tint", "alpha", and "advanced".
The following example illustrates use of this property:
//change the colorMode of the first element in the first frame, top layer
fl.getDocumentDOM().getTimeline().layers[0].frames[0].elements[0].colorMode = 'advanced';