diff --git a/QualityControl/public/app.css b/QualityControl/public/app.css
index 956128933..36bc92181 100644
--- a/QualityControl/public/app.css
+++ b/QualityControl/public/app.css
@@ -152,9 +152,9 @@
   }
 }
 
-.cursor-pointer {
-  cursor: pointer;
-}
+.cursor-pointer { cursor: pointer; }
+.cursor-grab { cursor: grab; }
+.cursor-inherit { cursor: inherit; }
 
 .header-layout {
   &.edit {
@@ -187,3 +187,33 @@
 .whitespace-nowrap {
   white-space: nowrap;
 }
+
+.drop-zone {
+  position: absolute;
+  height: 100%;
+  width: 50%;
+  pointer-events: none;
+
+  &.before {
+    left: 0;
+
+    &.active {
+      border-left: 2px solid var(--color-primary);
+    }
+  }
+
+  &.after {
+    right: 0;
+
+    &.active {
+      border-right: 2px solid var(--color-primary);
+    }
+  }
+}
+
+.pointer-events-auto {
+  pointer-events: auto;
+}
+.pointer-events-none {
+  pointer-events: none;
+}
diff --git a/QualityControl/public/layout/Layout.js b/QualityControl/public/layout/Layout.js
index 58740064f..81c805581 100644
--- a/QualityControl/public/layout/Layout.js
+++ b/QualityControl/public/layout/Layout.js
@@ -61,6 +61,10 @@ export default class Layout extends BaseViewModel {
     });
     this.cellHeight = 100 / this.gridListSize * 0.95; // %, put some margin at bottom to see below
     this.cellWidth = 100 / this.gridListSize; // %
+
+    this.isDragging = false;
+    this.dropTargetId = undefined;
+    this.position = undefined;
   }
 
   /**
@@ -777,4 +781,82 @@ export default class Layout extends BaseViewModel {
   ownsLayout(layoutOwnerId) {
     return this.model.session.personid == layoutOwnerId;
   }
+
+  /**
+   * Sets the current drop target for a drag-and-drop operation.
+   * This is typically used to render a visual indicator (like a blue line)
+   * in the UI showing where the dragged tab will be placed.
+   * @param {string|number} tabId - The ID of the tab currently being hovered over.
+   * @param {'before'|'after'} position - The side of the target tab where the drop indicator should appear.
+   */
+  setDropTarget(tabId, position) {
+    this.dropTargetId = tabId;
+    this.position = position;
+
+    this.notify();
+  }
+
+  /**
+   * Clears the current drop target state, usually when the drag operation
+   * is finished or the dragged item is no longer over a valid drop zone.
+   * This action typically causes the visual drop indicator to be hidden.
+   */
+  clearDropTarget() {
+    this.dropTargetId = undefined;
+    this.position = undefined;
+
+    this.notify();
+  }
+
+  /**
+   * Reorders the tabs in the internal array based on the drag source and drop target.
+   * This function calculates the correct index for insertion, accounting for the
+   * tab being removed from its original position.
+   * @param {string|number} sourceId - The ID of the tab that was dragged.
+   * @param {string|number} targetId - The ID of the tab that the source was dropped onto.
+   * @param {'before'|'after'} position - The placement relative to the target tab.
+   */
+  reorderTabs(sourceId, targetId, position) {
+    const sourceIndex = this.item.tabs.findIndex((t) => t.id === sourceId);
+    let targetIndex = this.item.tabs.findIndex((t) => t.id === targetId);
+
+    if (sourceIndex === -1 || targetIndex === -1) {
+      return;
+    }
+
+    if (position === 'after') {
+      targetIndex += 1;
+    }
+
+    const [movedTab] = this.item.tabs.splice(sourceIndex, 1);
+
+    if (sourceIndex < targetIndex) {
+      targetIndex--;
+    }
+
+    this.item.tabs.splice(targetIndex, 0, movedTab);
+
+    this.notify();
+  }
+
+  /**
+   * Sets the layout state to indicate that a tab drag-and-drop operation has begun.
+   * It typically triggers a redraw and enables pointer events on all drop zones via CSS.
+   */
+  startDragging() {
+    this.isDragging = true;
+
+    this.notify();
+  }
+
+  /**
+   * Resets the layout state to indicate that a tab drag-and-drop operation has ended,
+   * regardless of whether the drop was successful or cancelled.
+   * It typically triggers a redraw and disables pointer events on the drop zones via CSS.
+   */
+  stopDragging() {
+    this.isDragging = false;
+
+    this.notify();
+  }
 }
diff --git a/QualityControl/public/layout/view/header.js b/QualityControl/public/layout/view/header.js
index b254de5b0..25a69d272 100644
--- a/QualityControl/public/layout/view/header.js
+++ b/QualityControl/public/layout/view/header.js
@@ -143,15 +143,70 @@ const toolbarEditModeTab = (layout, tab, i) => {
    */
   const selectTab = () => layout.selectTab(i);
 
+  const dragActiveClass = layout.isDragging ? 'pointer-events-auto' : '';
+  const disableButtonsOnDragClass = layout.isDragging ? 'pointer-events-none' : '';
+  const dropZoneClass = (position) => layout.dropTargetId === tab.id && layout.position === position ? 'active' : '';
+
   return [
-    h('.btn-group.flex-fixed', [
-      h('button.br-pill.ph2.btn.btn-tab.whitespace-nowrap', { class: linkClass, onclick: selectTab }, tab.name),
-      selected && [
-        editTabButton(layout, linkClass, tab, i),
-        resizeGridTabDropDown(layout, tab),
-        deleteTabButton(layout, linkClass, i),
+    h(
+      '.btn-group.flex-fixed.relative.cursor-grab',
+      {
+        title: 'Drag the tab to re-arrange them',
+        draggable: true,
+        ondragstart: (e) => {
+          e.dataTransfer.setData('text/plain', tab.id);
+          layout.startDragging();
+        },
+        ondrop: (e) => {
+          layout.reorderTabs(e.dataTransfer.getData('text/plain'), layout.dropTargetId, layout.position);
+          layout.clearDropTarget();
+          layout.stopDragging();
+        },
+        ondragend: () => layout.stopDragging(),
+      },
+      [
+        h(
+          'button.br-pill.ph2.btn.btn-tab.whitespace-nowrap',
+          { id: 'btn-tab', class: `${linkClass} cursor-inherit`, onclick: selectTab },
+          tab.name,
+        ),
+        [
+          h(
+            '.drop-zone.before',
+            {
+              class: `${dragActiveClass} ${dropZoneClass('before')}`,
+              ondragenter: () => layout.setDropTarget(tab.id, 'before'),
+              ondragover: (e) => e.preventDefault(), // prevent default to allow drop
+              ondragleave: () => {
+                if (layout.dropTargetId === tab.id && layout.position === 'before') {
+                  layout.clearDropTarget();
+                }
+              },
+            },
+            '',
+          ),
+          h(
+            '.drop-zone.after',
+            {
+              class: `${dragActiveClass} ${dropZoneClass('after')}`,
+              ondragenter: () => layout.setDropTarget(tab.id, 'after'),
+              ondragover: (e) => e.preventDefault(), // prevent default to allow drop
+              ondragleave: () => {
+                if (layout.dropTargetId === tab.id && layout.position === 'after') {
+                  layout.clearDropTarget();
+                }
+              },
+            },
+            '',
+          ),
+          selected && [
+            editTabButton(layout, `${disableButtonsOnDragClass} ${linkClass}`, tab, i),
+            resizeGridTabDropDown(layout, tab),
+            deleteTabButton(layout, `${disableButtonsOnDragClass} ${linkClass}`, i),
+          ],
+        ].flat().filter(Boolean),
       ],
-    ]),
+    ),
     ' ',
   ];
 };
diff --git a/QualityControl/test/public/pages/layout-show.test.js b/QualityControl/test/public/pages/layout-show.test.js
index 1d96724a3..2a044a2b4 100644
--- a/QualityControl/test/public/pages/layout-show.test.js
+++ b/QualityControl/test/public/pages/layout-show.test.js
@@ -14,6 +14,7 @@
 import { strictEqual, ok, deepStrictEqual } from 'node:assert';
 import { delay } from '../../testUtils/delay.js';
 import { editedMockedLayout } from '../../setup/seeders/layout-show/json-file-mock.js';
+import { getElementCenter } from '../../testUtils/dragAndDrop.js';
 
 /**
  * Performs a series of automated tests on the layoutShow page using Puppeteer.
@@ -297,6 +298,39 @@ export const layoutShowTests = async (url, page, timeout = 5000, testParent) =>
     },
   );
 
+  await testParent.test(
+    'should reorder tabs via drag and drop in edit mode',
+    { timeout },
+    async () => {
+      const originalTabNames = await page.$$eval('#btn-tab', (elements) =>
+        elements.map((element) => element.textContent.trim()));
+
+      const sourceTabSelector = '.btn-group.flex-fixed.relative:nth-child(1)';
+      const targetZoneSelector = '.btn-group.flex-fixed.relative:nth-child(2) .drop-zone.after';
+
+      const sourceCenter = await getElementCenter(page, sourceTabSelector);
+      const targetCenter = await getElementCenter(page, targetZoneSelector);
+
+      await page.mouse.move(sourceCenter.x, sourceCenter.y);
+      await page.mouse.down();
+
+      // We add 'steps' to make the move smoother, which helps trigger event
+      await page.mouse.move(targetCenter.x, targetCenter.y, { steps: 10 });
+
+      await delay(1000);
+
+      // Wait a moment for the 'active' class to appear in the UI
+      await page.waitForSelector('.drop-zone.after.active');
+
+      await page.mouse.up();
+
+      const tabNames = await page.$$eval('#btn-tab', (elements) =>
+        elements.map((element) => element.textContent.trim()));
+
+      strictEqual(tabNames[1], originalTabNames[0]);
+    }
+  );
+
   await testParent.test(
     'should show normal sidebar after Cancel click',
     { timeout },
diff --git a/QualityControl/test/testUtils/dragAndDrop.js b/QualityControl/test/testUtils/dragAndDrop.js
new file mode 100644
index 000000000..786c35c7d
--- /dev/null
+++ b/QualityControl/test/testUtils/dragAndDrop.js
@@ -0,0 +1,28 @@
+/**
+ * @license
+ * Copyright 2019-2020 CERN and copyright holders of ALICE O2.
+ * See http://alice-o2.web.cern.ch/copyright for details of the copyright holders.
+ * All rights not expressly granted are reserved.
+ *
+ * This software is distributed under the terms of the GNU General Public
+ * License v3 (GPL Version 3), copied verbatim in the file "COPYING".
+ *
+ * In applying this license CERN does not waive the privileges and immunities
+ * granted to it by virtue of its status as an Intergovernmental Organization
+ * or submit itself to any jurisdiction.
+ */
+
+/**
+ * Helper to get the center of an element.
+ * @param {object} page - Puppeteer page object.
+ * @param {string} selector - Element selector to look for.
+ * @returns {Promise<{x: number, y: number}>} A promise that resolves to the center x & y coordinates.
+ */
+export const getElementCenter = async (page, selector) => {
+  const element = await page.waitForSelector(selector);
+  const box = await element.boundingBox();
+  return {
+    x: box.x + box.width / 2,
+    y: box.y + box.height / 2
+  };
+};