diff --git a/.github/workflows/pipeline.yaml b/.github/workflows/pipeline.yaml
index ab17a5d01..5d42c8f91 100644
--- a/.github/workflows/pipeline.yaml
+++ b/.github/workflows/pipeline.yaml
@@ -5,11 +5,11 @@ on:
     inputs:
       gpu:
         description: "GPU type for regional calibration"
-        default: "T4"
+        default: "A100-40GB"
         type: string
       national_gpu:
         description: "GPU type for national calibration"
-        default: "T4"
+        default: "A100-40GB"
         type: string
       epochs:
         description: "Epochs for regional calibration"
@@ -116,8 +116,8 @@ jobs:
           MODAL_TOKEN_ID: ${{ secrets.MODAL_TOKEN_ID }}
           MODAL_TOKEN_SECRET: ${{ secrets.MODAL_TOKEN_SECRET }}
           PIPELINE_BRANCH: main
-          GPU: ${{ inputs.gpu || 'T4' }}
-          NATIONAL_GPU: ${{ inputs.national_gpu || 'T4' }}
+          GPU: ${{ inputs.gpu || 'A100-40GB' }}
+          NATIONAL_GPU: ${{ inputs.national_gpu || 'A100-40GB' }}
           EPOCHS: ${{ inputs.epochs || '1000' }}
           NATIONAL_EPOCHS: ${{ inputs.national_epochs || '1000' }}
           NUM_WORKERS: ${{ inputs.num_workers || '50' }}
diff --git a/Makefile b/Makefile
index 88c35899a..eee414205 100644
--- a/Makefile
+++ b/Makefile
@@ -5,9 +5,9 @@ SOI_TARGET_YEAR ?= 2023
 
 YEAR ?= 2024
 
-GPU ?= T4
+GPU ?= A100-40GB
 EPOCHS ?= 1000
-NATIONAL_GPU ?= T4
+NATIONAL_GPU ?= A100-40GB
 NATIONAL_EPOCHS ?= 1000
 BRANCH ?= $(shell git rev-parse --abbrev-ref HEAD)
 NUM_WORKERS ?= 8
diff --git a/changelog.d/default-publication-a100.changed.md b/changelog.d/default-publication-a100.changed.md
new file mode 100644
index 000000000..81febac75
--- /dev/null
+++ b/changelog.d/default-publication-a100.changed.md
@@ -0,0 +1 @@
+Default publication calibration fits to A100-40GB GPUs to avoid T4 memory failures on the full target matrix.
diff --git a/modal_app/pipeline.py b/modal_app/pipeline.py
index 39a437808..473007e23 100644
--- a/modal_app/pipeline.py
+++ b/modal_app/pipeline.py
@@ -904,9 +904,9 @@ def _new_run_metadata(
 )
 def run_pipeline(
     branch: str = "main",
-    gpu: str = "T4",
+    gpu: str = "A100-40GB",
     epochs: int = 1000,
-    national_gpu: str = "T4",
+    national_gpu: str = "A100-40GB",
     national_epochs: int = 1000,
     num_workers: int = 50,
     n_clones: int = 430,
@@ -2097,9 +2097,9 @@ def main(
     branch: str = "main",
     run_id: str = None,
     resume_run_id: str = None,
-    gpu: str = "T4",
+    gpu: str = "A100-40GB",
     epochs: int = 1000,
-    national_gpu: str = "T4",
+    national_gpu: str = "A100-40GB",
     national_epochs: int = 1000,
     num_workers: int = 50,
     n_clones: int = 430,
diff --git a/tests/unit/test_pipeline_source_contracts.py b/tests/unit/test_pipeline_source_contracts.py
index a022ef3fe..52d1d801d 100644
--- a/tests/unit/test_pipeline_source_contracts.py
+++ b/tests/unit/test_pipeline_source_contracts.py
@@ -20,6 +20,25 @@ def _name(node: ast.AST) -> str | None:
     return node.id if isinstance(node, ast.Name) else None
 
 
+def test_run_pipeline_defaults_to_a100_for_full_target_matrix() -> None:
+    tree = ast.parse(PIPELINE_SOURCE.read_text())
+    run_pipeline = _function_def(tree, "run_pipeline")
+    defaults = dict(
+        zip(
+            [
+                arg.arg
+                for arg in run_pipeline.args.args[-len(run_pipeline.args.defaults) :]
+            ],
+            run_pipeline.args.defaults,
+        )
+    )
+
+    assert isinstance(defaults["gpu"], ast.Constant)
+    assert defaults["gpu"].value == "A100-40GB"
+    assert isinstance(defaults["national_gpu"], ast.Constant)
+    assert defaults["national_gpu"].value == "A100-40GB"
+
+
 def test_promote_run_uses_single_full_release_promotion() -> None:
     tree = ast.parse(PIPELINE_SOURCE.read_text())
     promote_run = _function_def(tree, "promote_run")