diff --git a/.github/workflows/pythonapp.yml b/.github/workflows/pythonapp.yml
index 8bda575c22..0e898636fb 100644
--- a/.github/workflows/pythonapp.yml
+++ b/.github/workflows/pythonapp.yml
@@ -87,12 +87,12 @@ jobs:
         cat "requirements-dev.txt"
         python -m pip install --no-build-isolation -r requirements-dev.txt
         python -m pip list
-        python setup.py develop  # test no compile installation
+        python -m pip install -e .  # test no compile installation
       shell: bash
     - name: Run compiled (${{ runner.os }})
       run: |
-        python setup.py develop --uninstall
-        BUILD_MONAI=1 python setup.py develop  # compile the cpp extensions
+        python -m pip uninstall -y monai
+        BUILD_MONAI=1 python -m pip install -e .  # compile the cpp extensions
       shell: bash
     - name: Run quick tests (CPU ${{ runner.os }})
       run: |
diff --git a/docs/source/installation.md b/docs/source/installation.md
index b8befc10b4..646b34a23f 100644
--- a/docs/source/installation.md
+++ b/docs/source/installation.md
@@ -135,23 +135,23 @@ You can install it by running:
 
 ```bash
 cd MONAI/
-python setup.py develop
+pip install -e .
 ```
 
 or, to build with MONAI C++/CUDA extensions and install:
 
 ```bash
 cd MONAI/
-BUILD_MONAI=1 python setup.py develop
+BUILD_MONAI=1 pip install -e .
 # for MacOS
-BUILD_MONAI=1 CC=clang CXX=clang++ python setup.py develop
+BUILD_MONAI=1 CC=clang CXX=clang++ pip install -e .
 ```
 
 To uninstall the package please run:
 
 ```bash
 cd MONAI/
-python setup.py develop --uninstall
+pip uninstall -y monai
 
 # to further clean up the MONAI/ folder (Bash script)
 ./runtests.sh --clean
diff --git a/runtests.sh b/runtests.sh
index 9c8462f7cb..a1551fe8dd 100755
--- a/runtests.sh
+++ b/runtests.sh
@@ -145,9 +145,9 @@ function compile_cpp {
     ${cmdPrefix}"${PY_EXE}" -m pip uninstall -y monai
     if [[ "$OSTYPE" == "darwin"* ]];
     then  # clang for mac os
-        CC=clang CXX=clang++ ${cmdPrefix}"${PY_EXE}" setup.py develop --user
+        BUILD_MONAI=1 CC=clang CXX=clang++ ${cmdPrefix}"${PY_EXE}" -m pip install -e .
     else
-        ${cmdPrefix}"${PY_EXE}" setup.py develop --user
+        BUILD_MONAI=1 ${cmdPrefix}"${PY_EXE}" -m pip install -e .
     fi
 }