diff --git a/packages/main/cypress/specs/ComboBox.cy.tsx b/packages/main/cypress/specs/ComboBox.cy.tsx
index 0cd2803c939b..3f088601e625 100644
--- a/packages/main/cypress/specs/ComboBox.cy.tsx
+++ b/packages/main/cypress/specs/ComboBox.cy.tsx
@@ -187,21 +187,6 @@ describe("General Interaction", () => {
 		cy.get("[ui5-combobox]").should("have.prop", "focused", true);
 	});
 
-	it("shows focus outline on list item mousedown", () => {
-		cy.mount(
-			<ComboBox>
-				<ComboBoxItem text="One" />
-				<ComboBoxItem text="Two" />
-			</ComboBox>
-		);
-
-		cy.get("[ui5-combobox]").shadow().find(".inputIcon").realClick();
-		cy.get("[ui5-combobox]").shadow().find("[ui5-responsive-popover]").should("have.attr", "open");
-
-		cy.get("[ui5-cb-item]").first().shadow().find("li").realMouseDown();
-		cy.get("[ui5-cb-item]").first().should("have.prop", "focused", true);
-	});
-
 	it("tests Combo with two-column layout", () => {
 		cy.mount(
 			<ComboBox>
diff --git a/packages/main/src/ComboBox.ts b/packages/main/src/ComboBox.ts
index c7bc268c62c0..590accc326fc 100644
--- a/packages/main/src/ComboBox.ts
+++ b/packages/main/src/ComboBox.ts
@@ -1385,14 +1385,6 @@ class ComboBox extends UI5Element implements IFormInputElement {
 
 	_itemMousedown(e: MouseEvent) {
 		e.preventDefault();
-
-		const target = e.target as HTMLElement;
-		const listItem = target.closest<ComboBoxItem>("[ui5-cb-item], [ui5-cb-item-group]");
-
-		if (listItem) {
-			this._clearFocus();
-			listItem.focused = true;
-		}
 	}
 
 	_selectItem(e: CustomEvent<ListItemClickEventDetail>) {