diff --git a/src/google/adk/tools/discovery_engine_search_tool.py b/src/google/adk/tools/discovery_engine_search_tool.py
index 0e771ece4f..16e925b853 100644
--- a/src/google/adk/tools/discovery_engine_search_tool.py
+++ b/src/google/adk/tools/discovery_engine_search_tool.py
@@ -17,6 +17,7 @@
 from typing import Any
 from typing import Optional
 
+from google.api_core.client_options import ClientOptions
 from google.api_core.exceptions import GoogleAPICallError
 import google.auth
 from google.cloud import discoveryengine_v1beta as discoveryengine
@@ -71,9 +72,29 @@ def __init__(
     self._filter = filter
     self._max_results = max_results
 
+    # Extract location from data_store_id or search_engine_id
+    # Format: projects/{project}/locations/{location}/...
+    resource_id = data_store_id or search_engine_id
+    location = "global"
+    if resource_id:
+      parts = resource_id.split("/")
+      if "locations" in parts:
+        try:
+          loc_index = parts.index("locations") + 1
+          if loc_index < len(parts):
+            location = parts[loc_index]
+        except ValueError:
+          pass
+
+    client_options = None
+    if location != "global":
+      api_endpoint = f"{location}-discoveryengine.googleapis.com"
+      client_options = ClientOptions(api_endpoint=api_endpoint)
+
     credentials, _ = google.auth.default()
     self._discovery_engine_client = discoveryengine.SearchServiceClient(
-        credentials=credentials
+        credentials=credentials,
+        client_options=client_options,
     )
 
   def discovery_engine_search(
diff --git a/tests/unittests/tools/test_discovery_engine_search_tool.py b/tests/unittests/tools/test_discovery_engine_search_tool.py
index d10da252c7..0c2061ea24 100644
--- a/tests/unittests/tools/test_discovery_engine_search_tool.py
+++ b/tests/unittests/tools/test_discovery_engine_search_tool.py
@@ -76,6 +76,18 @@ def test_init_with_data_store_specs_without_search_engine_id_raises_error(
           data_store_id="test_data_store", data_store_specs=[{"id": "123"}]
       )
 
+  @mock.patch(
+      "google.cloud.discoveryengine_v1beta.SearchServiceClient",
+  )
+  def test_init_with_location(self, mock_search_client):
+    """Test initialization with location extracted from data_store_id."""
+    data_store_id = "projects/test-project/locations/us/collections/default_collection/dataStores/test-datastore"
+    DiscoveryEngineSearchTool(data_store_id=data_store_id)
+
+    # Check if SearchServiceClient was called with correct client_options
+    args, kwargs = mock_search_client.call_args
+    assert kwargs["client_options"].api_endpoint == "us-discoveryengine.googleapis.com"
+
   @mock.patch(
       "google.cloud.discoveryengine_v1beta.SearchServiceClient",
   )