diff --git a/ext/reflection/php_reflection.c b/ext/reflection/php_reflection.c
index 94d8bb7d149c..a43a436ca06f 100644
--- a/ext/reflection/php_reflection.c
+++ b/ext/reflection/php_reflection.c
@@ -6731,6 +6731,12 @@ ZEND_METHOD(ReflectionProperty, isReadable)
 					zval member;
 					ZVAL_STR(&member, ref->unmangled_name);
 					zend_call_known_instance_method_with_1_params(ce->__isset, obj, return_value, &member);
+
+					// if it's a reference, unwrap
+					if (Z_TYPE_P(return_value) == IS_REFERENCE) {
+						zend_unwrap_reference(return_value);
+					}
+
 					*guard &= ~ZEND_GUARD_PROPERTY_ISSET;
 					OBJ_RELEASE(obj);
 					return;
diff --git a/ext/reflection/tests/gh22000.phpt b/ext/reflection/tests/gh22000.phpt
new file mode 100644
index 000000000000..04c9214e60fe
--- /dev/null
+++ b/ext/reflection/tests/gh22000.phpt
@@ -0,0 +1,61 @@
+--TEST--
+GH-22000 - Ensure __isset is not returning a reference in ReflectionProperty::isReadable()
+--FILE--
+<?php
+class TestClass1 {
+    public int $a = 1;
+    public int $b;
+    public int $c;
+
+    public function __construct() {
+        unset($this->b);
+        unset($this->c);
+    }
+
+    public function __isset($name) {
+        return $name === 'b';
+    }
+
+    public function __get($name) {}
+}
+
+class TestClass2 {
+    public int $d;
+    public int $e;
+    public int $f;
+
+    public function __construct() {
+        unset($this->e);
+        unset($this->f);
+    }
+
+    public function &__isset($name) {
+        return $name === 'f';
+    }
+
+    public function __get($name) {}
+}
+
+
+function test($class) {
+    $rc = new ReflectionClass($class);
+    foreach ($rc->getProperties() as $rp) {
+        echo $rp->getName() . ' from global:';
+        var_dump($rp->isReadable(null, new $class));
+    }
+}
+
+test('TestClass1');
+test('TestClass2');
+?>
+--EXPECTF--
+a from global:bool(true)
+b from global:bool(true)
+c from global:bool(false)
+d from global:bool(false)
+e from global:
+Notice: Only variable references should be returned by reference in %s%eext%ereflection%etests%egh22000.php on line %d
+bool(false)
+f from global:
+Notice: Only variable references should be returned by reference in %s%eext%ereflection%etests%egh22000.php on line %d
+bool(true)