diff --git a/mypy/checker.py b/mypy/checker.py
index 33705c98e10c..5df290b408f3 100644
--- a/mypy/checker.py
+++ b/mypy/checker.py
@@ -6591,12 +6591,19 @@ def find_isinstance_check_helper(
                 if len(node.args) != 2:  # the error will be reported elsewhere
                     return {}, {}
                 if literal(expr) == LITERAL_TYPE:
-                    return conditional_types_to_typemaps(
-                        expr,
-                        *self.conditional_types_with_intersection(
-                            self.lookup_type(expr), self.get_isinstance_type(node.args[1]), expr
-                        ),
+                    original_type = self.lookup_type(expr)
+                    current_type = self.expr_checker.narrow_type_from_binder(expr, original_type)
+                    yes_type, no_type = self.conditional_types_with_intersection(
+                        original_type, self.get_isinstance_type(node.args[1]), expr
                     )
+                    if (
+                        self.binder.get(expr) is not None
+                        and yes_type is not None
+                        and not has_any_type(current_type)
+                        and is_subtype(current_type, yes_type, ignore_promotions=True)
+                    ):
+                        yes_type = current_type
+                    return conditional_types_to_typemaps(expr, yes_type, no_type)
             elif refers_to_fullname(node.callee, "builtins.issubclass"):
                 if len(node.args) != 2:  # the error will be reported elsewhere
                     return {}, {}
@@ -9347,6 +9354,46 @@ def is_valid_inferred_type(
     return not typ.accept(InvalidInferredTypes())
 
 
+def has_any_type(typ: Type) -> bool:
+    return _has_any_type(typ, set())
+
+
+def _has_any_type(typ: Type, seen: set[int]) -> bool:
+    if id(typ) in seen:
+        return False
+    seen.add(id(typ))
+    if isinstance(typ, TypeAliasType):
+        return any(_has_any_type(arg, seen) for arg in typ.args)
+    proper_type = get_proper_type(typ)
+    if isinstance(proper_type, AnyType):
+        return proper_type.type_of_any != TypeOfAny.special_form
+    if isinstance(proper_type, Instance):
+        return any(_has_any_type(arg, seen) for arg in proper_type.args)
+    if isinstance(proper_type, UnionType):
+        return any(_has_any_type(item, seen) for item in proper_type.items)
+    if isinstance(proper_type, TupleType):
+        return any(_has_any_type(item, seen) for item in proper_type.items)
+    if isinstance(proper_type, CallableType):
+        return any(_has_any_type(arg, seen) for arg in proper_type.arg_types) or _has_any_type(
+            proper_type.ret_type, seen
+        )
+    if isinstance(proper_type, TypeType):
+        return _has_any_type(proper_type.item, seen)
+    if isinstance(proper_type, TypeVarType):
+        return any(_has_any_type(value, seen) for value in proper_type.values) or _has_any_type(
+            proper_type.upper_bound, seen
+        )
+    if isinstance(proper_type, TypeVarTupleType):
+        return _has_any_type(proper_type.upper_bound, seen)
+    if isinstance(proper_type, TypedDictType):
+        return any(_has_any_type(item, seen) for item in proper_type.items.values())
+    if isinstance(proper_type, Overloaded):
+        return any(_has_any_type(item, seen) for item in proper_type.items)
+    if isinstance(proper_type, UnpackType):
+        return _has_any_type(proper_type.type, seen)
+    return False
+
+
 class InvalidInferredTypes(BoolTypeQuery):
     """Find type components that are not valid for an inferred type.
 
diff --git a/mypy/ipc.py b/mypy/ipc.py
index 08ca0caf75f1..e02499302b00 100644
--- a/mypy/ipc.py
+++ b/mypy/ipc.py
@@ -340,7 +340,7 @@ def connection_name(self) -> str:
             # for AF_UNIX sockets
             return os.path.join(self.sock_directory, self.name)
         else:
-            name = self.sock.getsockname()
+            name: object = self.sock.getsockname()
             assert isinstance(name, str)
             return name
 
diff --git a/test-data/unit/check-typeis.test b/test-data/unit/check-typeis.test
index 65ee837452f5..6b63f9aa080c 100644
--- a/test-data/unit/check-typeis.test
+++ b/test-data/unit/check-typeis.test
@@ -26,6 +26,25 @@ def main(a: Union[Point, Line, int]) -> None:
 
 [builtins fixtures/tuple.pyi]
 
+[case testTypeIsAndIsinstanceWithGenericAlias]
+from typing import Any, Generic, TypeVar
+from typing_extensions import TypeAlias, TypeIs
+
+T = TypeVar("T")
+class Slice(Generic[T]): pass
+
+SliceInt: TypeAlias = Slice[int | None]
+SliceStr: TypeAlias = Slice[str | None]
+
+def is_slice_int(obj: Any) -> TypeIs[SliceInt]: pass
+
+def main(obj: SliceInt | SliceStr) -> None:
+    if is_slice_int(obj):
+        pass
+    elif isinstance(obj, Slice):
+        reveal_type(obj)  # N: Revealed type is "__main__.Slice[builtins.str | None]"
+[builtins fixtures/isinstance.pyi]
+
 [case testTypeIsTypeArgsNone]
 from typing_extensions import TypeIs
 def foo(a: object) -> TypeIs:  # E: TypeIs must have exactly one type argument