diff --git a/src/SelectInput/index.tsx b/src/SelectInput/index.tsx
index 79980956..a34a260b 100644
--- a/src/SelectInput/index.tsx
+++ b/src/SelectInput/index.tsx
@@ -147,7 +147,8 @@ export default React.forwardRef<SelectInputRef, SelectInputProps>(function Selec
       }
 
       // Open dropdown when a valid open key is pressed
-      if (isValidateOpenKey(which)) {
+      const isModifier = event.ctrlKey || event.altKey || event.metaKey;
+      if (!isModifier && isValidateOpenKey(which)) {
         toggleOpen(true);
       }
     },
diff --git a/tests/Select.test.tsx b/tests/Select.test.tsx
index 34afca48..ebd495c5 100644
--- a/tests/Select.test.tsx
+++ b/tests/Select.test.tsx
@@ -1008,6 +1008,36 @@ describe('Select.Basic', () => {
     expectOpen(container, true);
   });
 
+  it('not open on browser hotkeys with modifier keys', () => {
+    const { container } = render(
+      <Select>
+        <Option value="1">1</Option>
+        <Option value="2">2</Option>
+      </Select>,
+    );
+
+    const inputEle = container.querySelector('input');
+
+    // Ctrl+key combinations (e.g., Ctrl+F for find, Ctrl+S for save)
+    keyDown(inputEle, KeyCode.F, { ctrlKey: true });
+    expectOpen(container, false);
+
+    keyDown(inputEle, KeyCode.S, { ctrlKey: true });
+    expectOpen(container, false);
+
+    // Alt+key combinations
+    keyDown(inputEle, KeyCode.F, { altKey: true });
+    expectOpen(container, false);
+
+    // Meta+key combinations (e.g., Cmd+key on Mac)
+    keyDown(inputEle, KeyCode.F, { metaKey: true });
+    expectOpen(container, false);
+
+    // Regular key without modifiers should still open
+    keyDown(inputEle, KeyCode.NUM_ONE);
+    expectOpen(container, true);
+  });
+
   it('close after select', () => {
     const { container } = render(
       <Select>
diff --git a/tests/utils/common.ts b/tests/utils/common.ts
index d10ebe4c..e197f277 100644
--- a/tests/utils/common.ts
+++ b/tests/utils/common.ts
@@ -110,8 +110,12 @@ export function injectRunAllTimers(jest: Jest) {
   });
 }
 
-export function keyDown(element: HTMLElement, keyCode: number) {
-  const event = createEvent.keyDown(element, { keyCode });
+export function keyDown(
+  element: HTMLElement,
+  keyCode: number,
+  options?: Partial<KeyboardEvent>,
+) {
+  const event = createEvent.keyDown(element, { keyCode, ...options });
   Object.defineProperties(event, {
     which: { get: () => keyCode },
   });